At least two lizards in California have a protein in their blood that kills borrelia
, which has slowed (but not stopped) its spread. When I left PA in the late 90s, I felt like I was escaping Lyme disease - one group of trail runners I knew estimates the prevalence of Lyme in its ranks at 70%
- but by the mid-teens I had already started seeing cases of Bell's palsy caused by Lyme - it's here. But still not as bad.
From microbenotes.com. Note that the classic target lesion occurs in only about 50% of cases, meaning that just because you never saw a target lesion, doesn't mean it's not Lyme.
No word on whether therapeutics are being based off this protein but it seems like an obvious move.