Above: Hood, Adams, St. Helens ad Rainier in one picture. Obviously there's no straight line that connects the four. From Reddit.
I've long been obsessed with the Sutter Buttes for similar reasons, i.e. their isolation from other Cascades. The Buttes are the southernmost Cascade, isolated in California's Central Valley north of Sacramento, and part of the argument for why they are NOT Cascades (for those who hold such a view) is that they're off-trend. I expect this technique could tell us WHY they're off-trend, and why the Buttes came up as a ring of small volcanoes, rather than a shield or a single peak.